Pilot Project Program of

Duke’s Center for Comparative Biology of Vulnerable Populations

 

 

1         Purpose of the Pilot Project Program

Duke’s Center for Comparative Biology of Vulnerable Populations (CCBVP) was funded in May 2004 by the National Institute of Environmental Health Sciences to support research aimed at understanding how biological, physiological, and social aspects of vulnerability alter the effect of the environment on human health.  The theme of the Center is broadly-based and interdisciplinary by design, and addresses the complex etiology and pathogenesis of diseases caused by environmental factors.  The Center includes three research cores (Neurobiology and Neurodevelopmental Disease, Pulmonary Biology and Disease, and Environmental Health Policy) and four facility cores (DNA Microarray, Proteomics, Inhalational Toxicology, and Advanced Computational Technologies).  For more information, please see the CCBVP website: www.env.duke.edu/ccbvp.

The CCBVP now invites a third round of pilot project applications to support research on human health and vulnerability to environmental influences; in particular, the effect of various aspects of vulnerability (age, geographic factors, co-morbid diseases, nutritional status, race, economic status, or genetics) on the relationship between environmental factors and health.    Successful applications will focus on neurodevelopmental disorders, environmental lung disease, and/or environmental health policy.  Proposals that are collaborative across the interest areas of the CCBVP are especially encouraged.  New investigators in environmental health research are encouraged to apply and will be given special consideration. 

 

2         Eligible Applicants

All Duke University faculty, with the exception of members of the CCBVP’s Internal Advisory Committee, are eligible to apply for funding

 

3         Available Funds and Resources

Funding in the amount of $150,000 is available to fund one-year projects in either the $5,000-15,000 range or the $15,000-50,000 range.  In addition to the funds provided by the Pilot Project Program, the CCBVP resources available to support new projects include: consultation, access to equipment, and discounted services from the four facility cores.  Services from the four facility cores will be discounted to 25% of the real costs.  These services include:

  • DNA Microarray Facility Core

Primary contact: Joseph Nevins, 684-2746, j.nevins@duke.edu

    • Consultation on design of microarray experiments
    • Provision of DNA microarrays that are enhanced for EHSRC projects by adding to the standard collection of sequences based on identification of genes important for environmental studies
    • Microarrays that will allow various cross-species comparisons (human vs. mouse vs. zebrafish vs. C. elegans)
  • Proteomics Facility Core

Primary contact: Dhaval Patel, ddpatel@med.unc.edu

    • Cellular protein profiling (flow cytometry)
    • Soluble protein profiling (protein arrays: bead-based arrays for cytokine profiling, custom and prefabricated)
    • Discovery proteomics (protein-protein interactions, surface plasmon resonance)

 

  • Inhalational Toxicology Facility Core

Primary contact: Michael Foster, 668-0382, foste028@mc.duke.edu

    • Pulmonary function assessment
    • Airway bronchoprovocation
    • Human/mouse exposure
    • Human Bronchoscopy with bronchoalveolar lavage
  • Advanced Computational Technologies Facility Core

Primary contact: Mike West, 684-8842, mw@stat.duke.edu

o      Consulting, advice, guidance and in some cases analysis for research projects

o      Consulting, advice, guidance and in some cases analysis for DNA microarray and proteomic studies

o      Bioinformatics support for genetic studies

Only one year of support will be awarded. The budget for a pilot project may include: supplies; salary support for technicians, research assistants, and graduate students; research related travel (but not travel to scientific meetings); and other justifiable research expenses.  Investigators should contact facility cores for information on costs of facility core services for specific research projects.  Faculty salary and indirect cost are not allowable expenses.  Subcontracts cannot be issued to institutions outside Duke.

 

4         Email of Intent

Prospective applicants must submit an email of intent that includes the following information:

  • Descriptive title of the proposed research
  • Name, title, departmental affiliation, address, email address, and telephone number of the proposed Principal Investigator
  • Name, title, and departmental affiliation of collaborating investigators

The email of intent is designed to facilitate a rapid review process and must be received by 15 February 2006. Please send your email of intent to jill.diaz@duke.edu with a subject line of “CCBVP Pilot Project Program Email of Intent”.

 

5         Application Requirements

 

5.1        Small Grants – $5,000-15,000

Abstract (250 words maximum)

Research plan (5 page maximum – single spaced, 12 point font, 1” margins all the way around) including responses to the following four questions:

  • What hypothesis do you intend to test?
  • Why is the work important?
  • What have you already done related to the proposed work?
  • What research methods will you use to undertake the work?

Appendix materials (1 page maximum – single spaced, 12 point font, 1” margins all the way around) including:

  • Research schedule and milestones

·       Collaborative nature of the project

·       Relevance to mission of the CCBVP 

  • Planned utilization of Facility Core services
  • Potential for future grant support

Budget and justification (1 page maximum)

Curriculum vitae OR NIH biosketch for each investigator including current grant support and limited to four pages for each investigator

Letter of acknowledgement that the proposed research is interacting with at least one of the scientific components of the Center.  This letter must come from the Center Director, Deputy Director, Associate Director, or one of the Research Core Directors.  This letter is written after an applicant discusses their proposed research with one of the above.

 

5.2        Larger Grants – $15,000-50,000

Abstract (250 words maximum)

Research plan (10 page maximum – single spaced, 12 point font, 1” margins all the way around) including responses to the following four questions:

  • What hypothesis do you intend to test?
  • Why is the work important?
  • What have you already done related to the proposed work?
  • What research methods will you use to undertake the work?

Appendix materials (1 page maximum – single spaced, 12 point font, 1” margins all the way around) including:

  • Research schedule and milestones

·       Collaborative nature of the project

·       Relevance to mission of the EHSRC 

  • Planned utilization of Facility Core services
  • Potential for future grant support

Budget and justification (1 page maximum)

Curriculum vitae OR NIH biosketch for each investigator including current grant support and limited to four pages for each investigator

Letter of acknowledgement that the proposed research is interacting with at least one of the scientific components of the Center.  This letter must come from the Center Director, Deputy Director, Associate Director, or one of the Research Core Directors.  This letter is written after an applicant discusses their proposed research with one of the above.

 

5.3        Submission Format

Please compend all required elements into a single pdf document and submit via email to jill.diaz@duke.edu with the subject line of “EHSRC Pilot Project Program Submission”.

 

6         Receipt and Review Schedule

Email of intent receipt date: 15 February 2006

Application receipt date: 22 February 2006

Grant review: March 2006

Project start date: 1 April 2006


 

7         Inquiries

We welcome the opportunity to answer questions from potential applicants. Additional information on each of the research and facility cores can be obtained by contacting Marie Lynn Miranda. Please direct inquiries related to this funding announcement to:


Richard Di Giulio, PhD

Director, Duke CCBVP

Nicholas School of the Environment and Earth Sciences

Telephone: 613-8024

Email: richd@duke.edu

 

Marie Lynn Miranda, PhD

Deputy Director, Duke CCBVP

Director, Duke CCBVP Pilot Project Program

Nicholas School of the Environment and Earth Sciences

Telephone: 613-8023

Email: mmiranda@duke.edu

 

Jo Rae Wright, PhD

Director, Duke CCBVP Pulmonary Biology and Disease Research Core

Department of Cell Biology

Telephone: 684-8040

Email: j.wright@cellbio.duke.edu

 

Marcy Speer, PhD

Director, Duke CCBVP Neurobiology and Neurodevelopmental Disease Research Core

Center for Human Genetics

Telephone: 684-2702

Email: marcy@chg.mc.duke.edu

 

Christopher Schroeder, JD

Director, Duke CCBVP Environmental Health Policy Research Core

Duke School of Law

Telephone: 684-7096

Email: schroeder@law.duke.edu